indoor biotechnologies/LoTox™ D. pteronyssinus Antigen (LTN-DPE-1)/1/LTN-DPE-1,indoor biotechnologies,,indoor biotechnologies,inbio,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：indoor biotechnologies/LoTox™ D. pteronyssinus Antigen (LTN-DPE-1)/1/LTN-DPE-1

产品编号：LTN-DPE-1

市场价：¥8300.00

场地：美国(厂家直采)

产品分类：蛋白类>多肽>多肽合成>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$415.00

品牌： indoor biotechnologies

公司：indoorbiotechnologies

公司分类：

商品介绍

Allergen:	Dermatophagoides pteronyssinus, house dust mite
Source:	D.pteronyssinus spent mite culture
Mol. Wt:	Der p 1: 24kD and Der p 2: 14kD
ELISA	See product insert (defined amounts of Der p 1 and Der p 2)
Concentration:	See product insert.
Volume	1 ml
Formulation:	Preservative and carrier-free in sterile, endotoxin-free, phosphate buffered saline, pH 7.4. Sterile filtered.
Storage:	Store at -20ºC. Do not allow product to remain at 4°C or room temperature for extended periods of time. Refreeze unused portion and aliquot into smaller quantities if necessary to avoid freeze/thaw cycles.
Notes	A LoToxTM product: Endotoxin ≤ 0.03 EU/µg. Cysteine protease activity: See product insert. Serine protease activity: See product insert. Use sterile tips to avoid contamination of product.
PDB:
Product Resources:	LoTox™ D. pteronyssinus Antigen Certificate of Analysis
Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.
References:
Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on Group 1 and Group II Dermatophagoides spp. Allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990;144:1353-1360. Schultz O, Laing P, Sewell HF, Shakib F. Der p 1, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur J Immunol 1995;25:3191-3194. King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998; 161:3645-3651. Gough L, Schultz O, Sewell HF, Shakib F. The cysteine protease activity of the major house dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody responses. J Exp Med 1999; 190:1897-1901. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MD, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104:123-133. Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2008, Dec. 7. Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structure of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol, 2009;386:520-530.

品牌介绍

Indoor Biotechnologies 由三家附属公司组成，INDOOR Biotechnologies Inc.（IBI），位于美国弗吉尼亚州夏洛茨维尔，INDOOR Biotechnologies Limited（IBL）位于英国卡迪夫，INDOOR Biotechnologies India（IBIndia），新设立于班加罗尔。Indoor Biotechnologies 遍布全球，在日本，中国和韩国拥有授权分销商，在全球约50个国家/地区销售。 Indoor Biotechnologies 生产纯化的天然和重组过敏原，用于研究和开发过敏诊断和疫苗。该产品系列目前包括 50 种纯化的过敏原，其制造具有高纯度和生物活性。这包括具有低内毒素含量的 LoTox™ 过敏原，专为过敏和哮喘的免疫学研究而设计。

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